Little or no pain or discomfort2
First symptoms may occur
when joint in use2
Frequent pain and stiffness when
walking, running, and bending2
Great pain, stiffness, and reduced
range of motion when walking2
Stage 1
Stage 2
Stage 3
Stage 4
High molecular weight linear HA binds
to CD44 receptors PROMOTING activation of
ANTI-INFLAMMATORY cytokine production.3,4
Low molecular weight linear HA binds
suboptimally to CD44 receptors PROMOTING
PRO-INFLAMMATORY cytokine production.3,4
high molecular weight ha
low molecular weight ha
Not all HA injections are the same
All HA injections provide lubrication and shock
absorption, but only certain HAs may slow down OA
of the knee and preserve knee function.7,10
Hyaluronic Acid
(HA) Injection
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Hyaluronic Acid
(HA) Injection
Repeat injections with
high molecular weight HA
may help enhance the way
the synovial fluids' high
molecular weight HA moves
throughout the knee. This
can improve the joint's ability
to make its own HA.7-9
HA injections can have two
important elements:
In clinical trials, HAs with high molecular
weight made a clinically significant
difference in pain relief when compared
to HAs with low molecular weight.1,4,6
high molecular weight
LINEAR Structure
In a healthy knee, natural fluid has a linear
structure and high molecular weight. Linear
high molecular weight HA most closely
resembles the HA naturally found in the knee.4
Choosing the right HA
provides both
  • Joint lubrication
  • Increased shock absorption
physical benefits
cellular benefits
  • Reduces pain by coating nerve endings1,6
  • Reduces inflammation1,6
  • Protects cartilage, decreases wear and tear1,6
  • Helps your body create more of your own naturally made HA3
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hyaluronic acid
(HA) injection
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